CD4 Rabbit Polyclonal Antibody

Function

The CD4 gene encodes the T4 antigen, a glycoprotein of approximately 55 kDa, expressed on the surface of helper T lymphocytes.CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in major histocompatibility complex class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as interleukin-15 receptors and bind to the HIV receptors, binding directly to the HIV envelope protein GP120.

Background References

1. Parnes J.R., Hunkapiller T.; "L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system."; Immunol. Rev. 100:109-127(1987).

2. Gorman S.D., Tourvieille B., Parnes J.R.; "Structure of the mouse gene encoding CD4 and an unusual transcript in brain.";Proc. Natl. Acad. Sci. U.S.A. 84:7644-7648(1987).

3. Rudd CE.CD4,CD8and the TCR-CD3complex:a novel class of proˉtein-tyrosine kinase receptor.Immunol Today,1990,11(11):400-406.

Tissue Specificity

Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

Post-translational Modification

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.; Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.

Subcellular Location

Cell membrane

UNIPROT

SwissProt: P01730 Human

Synonyms