CD68 Rabbit Polyclonal Antibody

Function

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

Background References

1. Chistiakov DA. et. al. CD68/macrosialin: not just a histochemical marker. Lab Invest. 2017 Jan;97(1):4-13.

2. Tochio H. et. al. CD68-Positive Cells in Hepatic Angiomyolipoma. Oncology. 2017;92 Suppl 1:35-39.

Sequence Similarity

Belongs to the LAMP family.

Tissue Specificity

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

Post-translational Modification

N- and O-glycosylated.

Subcellular Location

Cell membrane, endosome membrane, lysosome membrane.

UNIPROT

SwissProt: P34810 Human

SwissProt: P31996 Mouse

Synonyms