CD9 Rabbit Polyclonal Antibody

Function

CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. Protein exists in three forms, and is known to carry covalently linked fatty acids. It is involved in platelet activation, aggregation, in cell adhesion, cell motility and tumor metastasis. It regulates paranodal junction formation, and is also required for gamete fusion.

Background References

1. Higashihara M., Takahata K., Yatomi Y., Nakahara K., Kurokawa K.; "Purification and partial characterization of CD9 antigen of human platelets."; FEBS Lett. 264:270-274(1990).

2. Ikeyama S., Koyama M., Yamaoko M., Sasada R., Miyake M.; "Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA."; J. Exp. Med. 177:1231-1237(1993).

3. Rubinstein E., Benoit P., Billard M., Plaisance S., Prenant M., Uzan G., Boucheix C.; "Organization of the human CD9 gene."; Genomics 16:132-138(1993).

Sequence Similarity

Belongs to the tetraspanin (TM4SF) family.

Tissue Specificity

Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells.

Post-translational Modification

Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P21926 Human

SwissProt: P40240 Mouse

Synonyms