CD93 Mouse Monoclonal Antibody [E10-A10]

Function

The CD93 antigen is a 652 amino acid cell-surface glycoprotein expressed by monocytes, neutrophils, platelets, microglia, and endothelial cells. CD93 was originally thought to be a putative receptor for the complement component C1q, a serum glycoprotein which plays an integral role in the activation of the classical pathway in response to immune complexes. As a result, in the literature the CD93 gene product has also been referred to as C1QR1 and C1qRp as well as MXRA4 (Matrix-remodeling-associated protein 4). Recent studies suggest that the CD93 antigen plays a role in intercellular adhesion and in clearance of apoptotic cells. CD93 is a heavily O-glycosylated, type I transmembrane protein consisting of an N-terminal domain with homology to C-type lectin domains, a tandem array of EGF-like domains, a single transmembrane domain and a short cytoplasmic tail.

Background References

1. Kao YC et al. The epidermal growth factor-like domain of CD93 is a potent angiogenic factor. PLoS One 7(12):e51647 (2012).

2. Ikewaki N et al. Flow cytometric identification of CD93 expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood. J Clin Immunol 30(5):723-33 (2010).

Subcellular Location

Membrane.

UNIPROT

SwissProt: Q9NPY3 Human

Synonyms