CD94 Recombinant Mouse Monoclonal Antibody [PSH14-52]
Catalog# HA601491
CD94 Recombinant Mouse Monoclonal Antibody [PSH14-52]
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FC
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Human
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unconjugated
Overview
Product Name
CD94 Recombinant Mouse Monoclonal Antibody [PSH14-52]
Antibody Type
Recombinant Mouse Monoclonal Antibody
Immunogen
Recombinant protein within Human CD94 aa 32-179 (Extracellular).
Species Reactivity
Human
Validated Applications
FC
Molecular Weight
Predicted band size: 21 kDa
Positive Control
Human lymphocytes.
Conjugation
unconjugated
Clone Number
PSH14-52
Reactivity Data
| FC | |
|---|---|
| Human |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 1% BSA, 0.2% Proclean 950.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
-
FC
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1:1,000
Target
Function
CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene. The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.
Background References
1. Liu X et al. Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance. Cancer Cell. 2023 Feb
2. Ngiow SF et al. LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity. Cell. 2024 Aug
Subcellular Location
Cell membrane.
UNIPROT
Synonyms
CD 94 antibody
CD94 antibody
CD94 antigen antibody
Killer cell lectin like receptor subfamily D member 1 antibody
Killer cell lectin-like receptor subfamily D member 1 antibody
KLRD 1 antibody
KLRD1 antibody
KLRD1 protein antibody
KLRD1_HUMAN antibody
KP 43 antibody
ExpandImages
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Flow cytometric analysis of human lymphocytes labeling CD94.
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA601491, 1/1,000) (red). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Mouse IgG Secondary antibody (HA1125) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
APC Conjugated CD94 Recombinant Mouse Monoclonal Antibody [PSH14-52]
Application: FC
Reactivity: Human
Conjugate: APC
