COMP Rabbit Polyclonal Antibody
Catalog# ER1906-53
COMP Rabbit Polyclonal Antibody
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WB
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Human
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unconjugated
Overview
Product Name
COMP Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
KLH conjugated synthetic peptide derived from human COMP 221-320/757
Species Reactivity
Human
Validated Applications
WB
Molecular Weight
83 KDa
Positive Control
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage Buffer
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:500-2000
Target
Function
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Background References
暂无
Subcellular Location
Secreted, extracellular space, extracellular matrix.
UNIPROT
Synonyms
cartilage oligomeric matrix protein (pseudoachondroplasia
epiphyseal dysplasia 1
multiple) antibody
Cartilage oligomeric matrix protein antibody
Cartilage oligomeric matrix protein precursor antibody
COMP antibody
COMP_HUMAN antibody
EDM 1 antibody
EDM1 antibody
EPD 1 antibody
ExpandImages
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Protein: Raji lysate;
Primary: rabbit Anti-COMP (ER1906-53) at 1:300;
Secondary: HRP conjugated Goat-Anti-rabbit IgG at 1: 5000;
Predicted band size: 83 kD
Observed band size: 77 kD
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
COMP Mouse Monoclonal Antibody [A10H2]
Application: WB,IHC-P
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
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