Caspase-12 Rabbit Polyclonal Antibody

Function

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Background References

1. Saleh M. et al. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429:75-79(2004).

Subcellular Location

Cytosol.

UNIPROT

SwissProt: Q6UXS9 Human

Synonyms

CASP 12 antibody

CASP-12 antibody

Casp12 antibody

CASP12P1 antibody

caspase 12 (gene/pseudogene) antibody

caspase 12 pseudogene 1 antibody

CASPC_HUMAN antibody

Inactive caspase-12 antibody

OTTHUMP00000207032 antibody