DUSP5 Rabbit Polyclonal Antibody

Function

Dual specificity protein phosphatase 5 is encoded by the DUSP5 gene, which is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.

Background References

1. "Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines."Kwak S.P., Dixon J.E.J. Biol. Chem. 270:1156-1160(1995)

2. "A novel dual specificity phosphatase induced by serum stimulation and heat shock."Ishibashi T., Bottaro D.P., Michieli P., Kelley C.A., Aaronson S.A.J. Biol. Chem. 269:29897-29902(1994)

Sequence Similarity

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Subcellular Location

Nucleus, Cytoplasm

UNIPROT

SwissProt: Q16690 Human

SwissProt: Q1HL35 Mouse

Synonyms