Dynamin 1 Rabbit Polyclonal Antibody

Function

Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity). The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.

Background References

1. Soulet F et al. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol Biol Cell 16:2058-2067 (2005).

2. Appenzeller S et al. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. Am J Hum Genet 95:360-370 (2014).

Sequence Similarity

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Subcellular Location

Cytoplasm, Cytoskeleton, Microtubule.

UNIPROT

SwissProt: Q05193 Human

SwissProt: P39053 Mouse

SwissProt: P21575 Rat

Synonyms

B dynamin antibody

D100 antibody

DNM 1 antibody

DNM antibody

DNM1 antibody

DYN1_HUMAN antibody

Dynamin antibody

Dynamin-1 antibody

Dynamin1 antibody