Putative multidrug resistance protein 1 Mouse Monoclonal Antibody [1-6]
Catalog# EM1701-51
Putative multidrug resistance protein 1 Mouse Monoclonal Antibody [1-6]
-
IF-Tissue
-
Rice
-
unconjugated
Overview
Product Name
Putative multidrug resistance protein 1 Mouse Monoclonal Antibody [1-6]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein within rice Putative multidrug resistance protein 1 aa 427-595 / 843.
Species Reactivity
Rice
Validated Applications
IF-Tissue
Molecular Weight
93 kDa
Positive Control
Rice.
Conjugation
unconjugated
Clone Number
1-6
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG1
Purification Method
Immunogen affinity purified.
Application Dilution
-
IF-Tissue
-
1:50-1:200
Target
Function
Multidrug resistance proteins (MRPs) are a subset of the ATP-binding cassette genes that are phase III detoxification proteins involved in transporting exogenous and endogenous compounds across cellular membranes. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. The MRPs characterized thus far are organic anion transporters. Many good substrates for these transporters are highly charged and do not penetrate the cell membrane.
Background References
1. E Bakos et al. Functional multidrug resistance protein (MRP) lacking the N-terminal transmembrane domain. J Biol Chem 273 pp. 32167-32175 (1998).
2. Kamlesh Sodani et al. Multidrug resistance associated proteins in multidrug resistance. Chin J Cancer. 31(2): 58–72 (2012).
Subcellular Location
Membrane.
UNIPROT
Images
-
Immunofluorescence analysis of paraffin-embedded Rice tissue using anti-Putative multidrug resistance protein 1 antibody (green). The nuclear counter stain is DAPI (blue).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"