Atg7 Rabbit Polyclonal Antibody (ER1802-18)

UNIPROT #

O95352

PROTEIN NAME

Atg7

SYNONYMS

1810013K23Rik antibody;APG7 autophagy 7 like antibody;APG7 autophagy 7-like (S. cerevisiae) antibody;APG7 like antibody;APG7, S. cerevisiae, homolog of antibody;APG7-like antibody;APG7L antibody;ATG 7 antibody;ATG12-activating enzyme E1 ATG7 antibody;ATG7 antibody;ATG7 autophagy related 7 homolog (S. cerevisiae) antibody;ATG7 autophagy related 7 homolog antibody;ATG7_HUMAN antibody;Atg7l antibody;Autophagy 7, S. cerevisiae, homolog of antibody;Autophagy related protein 7 antibody;Autophagy-related 7 (yeast) antibody;Autophagy-related protein 7 antibody;DKFZp434N0735 antibody;GSA 7 antibody;GSA7 antibody;hAGP7 antibody;Ubiquitin activating enzyme E1 like protein antibody;Ubiquitin-activating enzyme E1-like protein antibody;Ubiquitin-like modifier-activating enzyme ATG7 antibody

SEQUENCE SIMILARITIES

Belongs to the ATG7 family.

TISSUE SPECIFICITY

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.

POST-TRANSLATIONAL MODIFICATION

Acetylated by EP300.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (PubMed:34161705). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner .