LC3A Rabbit Polyclonal Antibody (ER1802-2)

UNIPROT #

Q9H492

PROTEIN NAME

LC3A

SYNONYMS

ATG8F antibody;Autophagy related protein LC3 A antibody;Autophagy related protein LC3 B antibody;Autophagy related ubiquitin like modifier LC3 A antibody;Autophagy related ubiquitin like modifier LC3 B antibody;Autophagy-related protein LC3 B antibody;Autophagy-related ubiquitin-like modifier LC3 B antibody;LC3 antibody;MAP1 light chain 3 like protein 1 antibody;MAP1 light chain 3 like protein 2 antibody;MAP1 light chain 3-like protein 2 antibody;MAP1A/1B light chain 3 A antibody;MAP1A/1B light chain 3 B antibody;MAP1A/1BLC3 antibody;MAP1A/MAP1B LC3 A antibody;MAP1A/MAP1B LC3 B antibody;MAP1A/MAP1B light chain 3 B antibody;MAP1ALC3 antibody;MAP1BLC3 antibody;MAP1LC3A antibody;Map1lc3b antibody;Microtubule associated protein 1 light chain 3 alpha antibody;Microtubule associated protein 1 light chain 3 beta antibody;Microtubule associated proteins 1A/1B light chain 3 antibody;Microtubule associated proteins 1A/1B light chain 3A antibody;Microtubule associated proteins 1A/1B light chain 3B antibody;Microtubule-associated protein 1 light chain 3 beta antibody;Microtubule-associated proteins 1A/1B light chain 3B antibody;MLP3B_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the ATG8 family.

TISSUE SPECIFICITY

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

POST-TRANSLATIONAL MODIFICATION

The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.; Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.

SUBCELLULAR LOCATION

Cytoskeleton. Endomembrane system. Autophagosome membrane.

FUNCTION

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene. Two transcript variants encoding different isoforms have been found for this gene. MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy. MAP1LC3A is regulated by several post-translational modifications. These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A, which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to interact with sequestosome 1.