Vitamin D Receptor Rabbit Polyclonal Antibody
Catalog# ER1802-40
Vitamin D Receptor Rabbit Polyclonal Antibody
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WB
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FC
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Human
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unconjugated
Overview
Product Name
Vitamin D Receptor Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within Human Vitamin D Receptor aa 371-420 / 427.
Species Reactivity
Human
Validated Applications
WB, FC
Molecular Weight
Predicted band size: 48 kDa
Positive Control
PC-3M, Human small intestine tissue lysate, LOVO.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:500-1:1,000
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FC
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1:50-1:100
Target
Function
The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9-cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.
Background References
暂无
Sequence Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Subcellular Location
Nucleus. Cytoplasm.
UNIPROT
Synonyms
1 25 dihydroxyvitamin D3 receptor antibody
1 antibody
1,25 dihydroxyvitamin D3 receptor antibody
1,25-@dihydroxyvitamin D3 receptor antibody
25-dihydroxyvitamin D3 receptor antibody
Member 1 antibody
NR1I1 antibody
Nuclear receptor subfamily 1 group I member 1 antibody
PPP1R163 antibody
Protein phosphatase 1, regulatory subunit 163 antibody
ExpandImages
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Western blot analysis of Vitamin D Receptor on PC-3M cell and human small intestine tissue lysate using anti-Vitamin D Receptor antibody at 1/500 dilution.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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