RBPMS Guinea Pig Polyclonal Antibody (ER1901-06)
Catalog# ER1901-06
Guinea Pig Polyclonal to RBPMS
-
WB
-
ELISA
-
Human
-
Mouse
Coating Concentration: 2 ug/ml, 100ul / well
Coating Buffer: Phosphate Buffered Saline, pH7.4
Secondary Antibody: Goat Anti-Guinea pig IgG (H+L), HRP Conjugated(1:1000)
Specifications
Product Type
Guinea Pig polyclonal primary
Product Name
RBPMS Guinea Pig Polyclonal Antibody (ER1901-06)
Immunogen
Synthetic peptide within human rbpms 1-30 conjugated to keyhole limpet haemocyanin.
Host
Guinea Pig
Positive Control
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
-
ELISA:1:1,000-1:5,000
-
WB
-
1:500-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
21 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
RBPMS
SYNONYMS
RNA-binding protein with multiple splicing;Heart and RRM expressed sequence
TISSUE SPECIFICITY
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
SUBCELLULAR LOCATION
Cytoplasm. Nucleus.
FUNCTION
This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
CITATIONS
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Scott-Hewitt, N., Perrucci, F., Morini, R., Erreni, M., Mahoney, M., Witkowska, A., Carey, A., Faggiani, E., Schuetz, L. T., Mason, S., Tamborini, M., Bizzotto, M., Passoni, L., Filipello, F., Jahn, R., Stevens, B., & Matteoli, M.
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. The EMBO journal, 39(16), e105380.
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