YARS2 Rabbit Polyclonal Antibody
Catalog# ER1902-50
YARS2 Rabbit Polyclonal Antibody
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IF-Tissue
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IHC-P
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Zebrafish
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unconjugated
Overview
Product Name
YARS2 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Recombinant protein within zebrafish YARS2 aa 251-474 / 474.
Species Reactivity
Zebrafish
Validated Applications
IF-Tissue, IHC-P
Target Molecular Weight
Predicted band size: 53 kDa
Positive Control
Zebrafish.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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IF-Tissue
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1:50-1:200
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IHC-P
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1:50-1:200
Target
Function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:613561]. MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.
Background References
1. Gaudet P et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12:449-462 (2011).
Sequence Similarity
Belongs to the class-I aminoacyl-tRNA synthetase family.
Subcellular Location
Cytosol. Mitochondrion.
UNIPROT
Synonyms
CGI 04 antibody
FLJ13995 antibody
mitochondrial antibody
MLASA2 antibody
mt TyrRS antibody
SYYM_HUMAN antibody
Tyrosine tRNA ligase 2 mitochondrial antibody
Tyrosine tRNA ligase antibody
Tyrosine tRNA ligase mitochondrial antibody
Tyrosine--tRNA ligase antibody
ExpandImages
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IF staining of YARS2 in Zebrafish embryos (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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Immunohistochemical analysis of paraffin-embedded Zebrafish embryos tissue section using anti-YARS2 antibody. Counter stained with hematoxylin.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"