TCF3 Recombinant Rabbit Monoclonal Antibody [SY0258] (ET1607-47)

UNIPROT #

Q9HCS4

PROTEIN NAME

TCF3

SYNONYMS

AGM8 antibody;bHLHb21 antibody;Class B basic helix-loop-helix protein 21 antibody;E12 antibody;E2A antibody;E2A immunoglobulin enhancer binding factors E12/E47 antibody;E47 antibody;Helix loop helix protein HE47 antibody;Immunoglobulin enhancer-binding factor E12/E47 antibody;Immunoglobulin transcription factor 1 antibody;ITF1 antibody;Kappa-E2-binding factor antibody;MGC129647 antibody;MGC129648 antibody;Negative vitamin D response element binding protein antibody;NOL1-TCF3 fusion antibody;TCF-3 antibody;Tcf3 antibody;TFE2_HUMAN antibody;transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) antibody;Transcription factor 3 antibody;transcription factor 3 variant 3 antibody;Transcription factor E2-alpha antibody;Transcription factor ITF-1 antibody;VDIR antibody;VDR interacting repressor antibody;vitamin D receptor-interacting repressor antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated following NGF stimulation.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and heterooligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression.