Skip to content

Thiophosphate ester Recombinant Rabbit Monoclonal Antibody [SD2020]

Usd: 385

Specification

Bulk Order Quote | Customization Request

Catalog# ET1612-11

Thiophosphate ester Recombinant Rabbit Monoclonal Antibody [SD2020]

Application

  • IP

Reactivity

  • Species independent

Conjugation

  • unconjugated

This product has been cited in peer reviewed publications, see list HERE

Overview

Product Name

Thiophosphate ester Recombinant Rabbit Monoclonal Antibody [SD2020]

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Thiophosphate ester lined to KLH.

Species Reactivity

Species independent

Validated Applications

IP

Conjugation

unconjugated

Clone Number

SD2020

RRID

AB_3070083

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • IP

  • 1:1,000

Target

Function

A thiophosphate (or phosphorothioate) is a family of compounds and anions with the general chemical formula PS4-xOx3-(x = 0, 1, 2, or 3). The state of protonation is usually not specified. They could be bound to as many as three protons for the neutral H3PS4-xOx species. Two protons correspond to the related monoanions, and one proton for the dianions. The trianions are highly basic and do not exist in appreciable concentrations in solution. Thiophosphates are tetrahedral anions, with the phosphorus at the center of the tetrahedron.

Background References

1. Leissing F et al. Substrate thiophosphorylation by Arabidopsis mitogen-activated protein kinases. BMC Plant Biol 16:48 (2016).

2. Li YH et al. AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Rep 12:599-609 (2015).

Images

  • Advantages of Using rAbs：<br />Increased Reproducibility<br />Because recombinant antibody production involves sequencing the antibody light and heavy chains, recombinant antibody production allows researchers more control over the antigen. <br />Ease of Scalability and Continuous Supply<br />In vitro methods for producing antibodies are amenable to large-scale production, meaning antibody availability is unlikely to become a limiting factor. Recombinant antibodies can be produced in weeks as opposed to months. <br />Animal-Free Tech<br />Once the antibody-producing genes are isolated, high-throughput in vitro manufacture can be implemented. This eliminates the numerous ethical and animal welfare concerns commonly associated with traditional monoclonal antibody production.

    Advantages of Using rAbs：
    Increased Reproducibility
    Because recombinant antibody production involves sequencing the antibody light and heavy chains, recombinant antibody production allows researchers more control over the antigen.
    Ease of Scalability and Continuous Supply
    In vitro methods for producing antibodies are amenable to large-scale production, meaning antibody availability is unlikely to become a limiting factor. Recombinant antibodies can be produced in weeks as opposed to months.
    Animal-Free Tech
    Once the antibody-producing genes are isolated, high-throughput in vitro manufacture can be implemented. This eliminates the numerous ethical and animal welfare concerns commonly associated with traditional monoclonal antibody production.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Citation