ANP Recombinant Rabbit Monoclonal Antibody [JM08-36]

Function

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. ANP, BNP, and CNP are highly homologous within the 17-residue ring structure formed by an intramolecular disulfide linkage. The genes which encode for ANP and BNP map to human chromosome 1p36.2. The gene which encodes for CNP maps to human chromosome 2q24-qter.

Background References

1. Zheng C et al. Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol 8:222 (2017).

2. Christoforou N et al. Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. PLoS One 8:e63577 (2013).

Sequence Similarity

Belongs to the natriuretic peptide family.

Tissue Specificity

[Urodilatin]: Detected in the kidney distal tubular cells (at protein level). Present in urine (at protein level).; [Atrial natriuretic peptide]: Detected in atrial and ventricular plasma samples, and in adipocytes (at protein level). Detected in urine in one study. However, was not detected in urine in another study. In the brain, predominantly expressed in the gray matter with very weak expression in the white matter (at protein level). Localizes to astrocyte-like structures throughout the white matter, and in the cerebral vessels detected in the leptomeningeal and parenchymal vessels, and endothelium and smooth muscle layers (at protein level). Relatively low levels of expression in the kidneys compared to urodilatin (at protein level).

Post-translational Modification

The precursor molecule is proteolytically cleaved by CORIN at Arg-123 to produce atrial natriuretic peptide. Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide. Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin.; [Atrial natriuretic peptide]: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulates its activity.; [Urodilatin]: Phosphorylation on Ser-129 decreases vasorelaxant activity.

Subcellular Location

Cell projection, Secreted.

UNIPROT

SwissProt: P01160 Human

Synonyms