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Human SLC16A3/MCT4, N-Twin Strep, C-His, Flag Tag Protein (HA210557)

Price: Regular price $379.00

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Catalog# HA210557

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  • Human

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Product Details

Product Type

Protein

Product Name

Human SLC16A3/MCT4, N-Twin Strep, C-His, Flag Tag Protein (HA210557)

Predicted molecular mass

20.5 kD

Protein construction description

A DNA sequence encoding the human SLC16A3/MCT4 protein (O15427) ((Asn 406-Val 465)-G4S-(Asn 406-Val 465)) was expressed with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus.

Accession

O15427

Protein construction

Twin Strep | SLC16A3/MCT4 ((406-465)ggggs(406-465)) | His | Flag

Source

E.coli

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

MCT4 (SLC16A3) is the third member of the monocarboxylate transporter (MCT) family and is involved in the transportation of metabolically important monocarboxylates such as lactate, pyruvate, acetate, and ketone bodies. MCT1 and MCT4 transport pH-related monocarboxylates, such as lactate and pyruvate. MCT11 may also be a proton-coupled monocarboxylate transporter. Monocarboxylate transporter 4 (MCT4), encoded by the SLC16A3 gene, is responsible for exporting lactic acid into the extracellular microenvironment, and an acidic microenvironment promotes cytokine production and remodels chronic inflammation, providing a link from glycolysis to inflammatory bowel disease (IBD). Overexpressed Solute Carrier Family 16 Member 3 (SLC16A3) plays a critical role in hypoxic cancer cell growth and proliferation, by expelling glycolysis-derived lactate across the plasma membrane.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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