Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]
Catalog# HA601029
Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]
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ELISA
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Zaire ebolavirus
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unconjugated
Overview
Product Name
Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Synthetic peptide within Zaire Ebola virus Envelope glycoprotein aa 400-450.
Species Reactivity
Zaire ebolavirus
Validated Applications
ELISA
Target Molecular Weight
Predicted band size: 74 kDa
Conjugation
unconjugated
Clone Number
A1-A6
RRID
Product Features
Form
Liquid
Concentration
2 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG2b
Purification Method
Protein G affinity purified.
Application Dilution
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ELISA
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1:10.000
Target
Function
Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, downregulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. Downregulates as well the function of host natural killer cells. Counteracts the antiviral effect of host BST2/tetherin that restricts release of progeny virions from infected cells. However, cooperates with VP40 and host BST2 to activate canonical NF-kappa-B pathway in a manner dependent on neddylation.
Background References
暂无
Subcellular Location
Virion membrane, Host cell membrane, Secreted.
Synonyms
GP 1,2 antibody
GP antibody
GP1 antibody
GP2 antibody
GP2-delta antibody
Spike glycoprotein antibody
Virion spike glycoprotein antibody
Images
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1. High specificity
Due to their recognition of only one epitope, mAbs are best known for their high specificity. Producing highly specific monoclonal antibodies supplies researchers with the benefits of improved target identification and less background signal.
2. Batch-to-batch reproducibility
Since a monoclonal antibody is made by cloning a unique while blood cell. All subsequent products developed from this antibody trace back to its original, unique parent cell. This makes for great batch-to-batch reproducibility.
3. Guaranteed long term supply
Hybridoma serves as a continuous source of monoclonal antibody.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"