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MMAF Recombinant Mouse Monoclonal Antibody [A5G11-R] (HA601261)

Price: Regular price $350.00

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Catalog# HA601261

Mouse Monoclonal to MMAF

Tested for

  • ELISA

Reacts with

  • Species independent

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Mouse monoclonal primary

Product Name

MMAF Recombinant Mouse Monoclonal Antibody [A5G11-R] (HA601261)

Immunogen

Mmaf coupled with ova.

Host

Mouse

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

A5G11-R

RRID

AB_3096504

APPLICATION DILUTION

  • ELISA

  • 1:5,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein A affinity purified.

Isotype

IgG1

TARGET

PROTEIN NAME

MMAF

SYNONYMS

MMAF antibody;Monomethyl auristatin F antibdy

FUNCTION

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.

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