NF-M Recombinant Antibody [JM11-20] - Chicken IgY (Chimeric)
Catalog# HA601507
NF-M Recombinant Antibody [JM11-20] - Chicken IgY (Chimeric)
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IHC-Fr
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Mouse
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HA610337
不含抗保成分
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unconjugated
Overview
Product Name
NF-M Recombinant Antibody [JM11-20] - Chicken IgY (Chimeric)
Antibody Type
Recombinant Chimeric Antibody
Immunogen
Synthetic peptide within Human NEFM aa 651-692 / 916.
Species Reactivity
Mouse
Validated Applications
IHC-Fr
Molecular Weight
Predicted band size: 102 kDa
Conjugation
unconjugated
Clone Number
JM11-20
Reactivity Data
| IHC-Fr | |
|---|---|
| Mouse |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgY
Purification Method
Protein A affinity purified.
Application Dilution
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IHC-Fr
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1:200
Target
Function
Neurofilament-M (NF-M), for neurofilament medium polypeptide, a member of the intermediate filament family, is a major component of neuronal cytoskeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Alzheimer's disease.
Background References
1. Li D et al. NEFM DNA methylation correlates with immune infiltration and survival in breast cancer. Clin Epigenetics. 2021 May
2. Sohrabi N et al. Regulatory Role of Insulin on Endogenous L1 ORF1 and NEFM Gene Expression through PI3K Signaling Pathway Specifically in Neuroblastoma Cell Line. Iran J Public Health. 2023 Mar
Subcellular Location
Cell projection, Cytoplasm, Cytoskeleton, Intermediate filament.
UNIPROT
Synonyms
150kDa medium antibody
NEF3 antibody
NEFM antibody
Neurofilament 3 antibody
NF160 antibody
NFM antibody
Images
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Application: IHC-Fr
Species: Mouse
Site: brain
Sample: Frozen section
Antibody concentration: 1/200
Antigen retrieval: Not required
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"