Bim Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SU0318] (HA750137)

UNIPROT #

O43521

PROTEIN NAME

Bim

SYNONYMS

BCL2 like 11 antibody;B2L11_HUMAN antibody;BAM antibody;Bcl 2 interacting protein Bim antibody;Bcl 2 related ovarian death agonist antibody;Bcl-2-like protein 11 antibody;BCL2 interacting mediator of cell death antibody;BCL2 like 11 (apoptosis facilitator) antibody;BCL2 like protein 11 antibody;Bcl2-interacting mediator of cell death antibody;Bcl2-L-11 antibody;Bcl2l11 antibody;BIM alpha6 antibody;BIM antibody;BIM beta6 antibody;BIM beta7 antibody;BimEL antibody;BimL antibody;BOD antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

TISSUE SPECIFICITY

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation. Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).; Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.

SUBCELLULAR LOCATION

Endomembrane system, Mitochondrion.

FUNCTION

Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.