p16INK4a Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SU0702] (HA750158)

UNIPROT #

P42771

PROTEIN NAME

p16INK4a

SYNONYMS

CCM2 antibody;CDK4 inhibitor p16 INK4 antibody;CDK4I antibody;CDKN2 antibody;CDKN2A antibody;Cell cycle negative regulator beta antibody;CMM2 antibody;Cyclin dependent kinase 4 inhibitor A antibody;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody;Cyclin Dependent Kinase Inhibitor 2A antibody;Cyclin dependent kinase inhibitor 2A isoform 4 antibody;Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody;Cyclin dependent kinase inhibitor p16 antibody;INK4 antibody;INK4A antibody;MLM antibody;MTS1 antibody;Multiple tumor suppressor 1 antibody;p14 antibody;p16 antibody;P16INK4 antibody;p16INK4a antibody;p19 antibody;p19Arf antibody;TP16 antibody

SEQUENCE SIMILARITIES

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

TISSUE SPECIFICITY

Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation seems to increase interaction with CDK4.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion (the omission of a part of the DNA sequence during replication) in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in many types of cancer. p16 can be used as a biomarker to improve the histological diagnostic accuracy of grade 3 cervical intraepithelial neoplasia (CIN). p16 is also implicated in the prevention of melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer and esophageal cancer.