Dnmt3a Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [ST04-78] (HA750169)

UNIPROT #

Q9Y6K1

PROTEIN NAME

Dnmt3a

SYNONYMS

DNA (cytosine 5) methyltransferase 3 alpha antibody;DNA (cytosine 5) methyltransferase 3A antibody;DNA (cytosine-5)-methyltransferase 3A antibody;DNA cytosine methyltransferase 3A2 antibody;DNA methyltransferase 3 alpha antibody;DNA methyltransferase 3a antibody;DNA methyltransferase HsaIIIA antibody;DNA MTase HsaIIIA antibody;DNM3A_HUMAN antibody;DNMT 3a antibody;DNMT antibody;Dnmt3a antibody;DNMT3A2 antibody;M.HsaIIIA antibody;MCMT antibody;OTTHUMP00000201149 antibody;TBRS antibody

SEQUENCE SIMILARITIES

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

TISSUE SPECIFICITY

Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.

POST-TRANSLATIONAL MODIFICATION

Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Chromosome.

FUNCTION

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.