ATP citrate lyase Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [ST51-07] (HA750171)

UNIPROT #

P53396

PROTEIN NAME

ATP citrate lyase

SYNONYMS

ACL antibody;Acly antibody;ACLY_HUMAN antibody;ATP citrate (pro-S) lyase antibody;ATP citrate lyase antibody;ATP citrate synthase antibody;ATP-citrate (pro-S-)-lyase antibody;ATP-citrate synthase antibody;ATPcitrate synthase antibody;ATPCL antibody;Citrate cleavage enzyme antibody;CLATP antibody;OTTHUMP00000164773 antibody

SEQUENCE SIMILARITIES

In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity. Phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455 (By similarity). Phosphorylation on Ser-455 is decreased by prior phosphorylation on the other 2 residues (By similarity).; ISGylated.; Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.; Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).

SUBCELLULAR LOCATION

Cytoplasm, cytosol.

FUNCTION

ATP-citrate synthase, also designated ATP-citrate lyase or citrate cleavage enzyme, is a cytoplasmic homotetramer belonging to the succinate/malate CoA ligase family. The gene coding for this protein maps against chromosome 17q12-q21. ATP-citrate synthase catalyses the formation of acetyl-CoA and oxaloacetate from citrate and CoA. This product, Acetyl-CoA, is necessary for both fatty acid and cholesterol biosynthesis. ATP citrate-lyase is important in the biosynthesis of acetylcholine in nervous tissue.