Phospho-JNK1/2/3 (T183 + T183 + T221) Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [ST500] (HA750173)

UNIPROT #

P45983

PROTEIN NAME

Phospho-JNK1/2/3 (JNK1(T183)+JNK2(T183)+JNK3(T221))

SYNONYMS

C Jun kinase 2 antibody;c Jun N terminal kinase 1 antibody;c Jun N terminal kinase 2 antibody;c Jun N terminal kinase 3 antibody;c-Jun N-terminal kinase 1 antibody;JNK 46 antibody;JNK 55 antibody;JNK antibody;JNK-46 antibody;JNK1 antibody;JNK1A2 antibody;JNK2 antibody;JNK21B1/2 antibody;JNK2A antibody;JNK2ALPHA antibody;JNK2B antibody;JNK2BETA antibody;JNK3 alpha protein kinase antibody;JNK3 antibody;JNK3A antibody;Jun kinase antibody;JUN N terminal kinase antibody;MAP kinase 10 antibody;MAP kinase 8 antibody;MAP kinase 9 antibody;MAP kinase p49 3F12 antibody;MAPK 10 antibody;MAPK 8 antibody;MAPK 9 antibody;MAPK10 antibody;mapk8 antibody;MAPK9 antibody;Mitogen activated protein kinase 10 antibody;Mitogen activated protein kinase 8 antibody;Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody;Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody;Mitogen activated protein kinase 9 antibody;Mitogen-activated protein kinase 8 antibody;MK08_HUMAN antibody;p493F12 antibody;p54a antibody;p54aSAPK antibody;p54bSAPK antibody;PRKM10 antibody;PRKM8 antibody;PRKM9 antibody;SAPK antibody;SAPK(beta) antibody;SAPK1 antibody;SAPK1a antibody;SAPK1b antibody;SAPK1c antibody;Stress activated protein kinase 1 antibody;Stress activated protein kinase 1a antibody;Stress activated protein kinase 1b antibody;Stress activated protein kinase 1c antibody;Stress activated protein kinase beta antibody;Stress activated protein kinase JNK1 antibody;Stress activated protein kinase JNK2 antibody;Stress activated protein kinase JNK3 antibody;Stress-activated protein kinase 1c antibody;Stress-activated protein kinase JNK1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2. May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1. Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity).

SUBCELLULAR LOCATION

Cytoplasm, Membrane, Mitochondrion, Nucleus.

FUNCTION

JNKs (c-Jun N-terminal kinases) belong to a family of MAP kinases that are involved in a variety of cellular processes, including transcriptional regulation and cellular proliferation, differentiation and development. JNK2 (c-Jun N-terminal kinase 2) and JNK3 (c-Jun N-terminal kinase 3) are 424 and 464 amino acid proteins, respectively, that each contain one protein kinase domain and use magnesium as a cofactor to catalyze the phosphorylation of target proteins, thereby playing a role in a variety of events throughout the cell. Both JNK2 and JNK3 exist as multiple alternatively spliced isoforms and are subject to post-translational phosphorylation on Thr 183 and Thr 221, respectively, an event which activates JNK2/JNK3 enzymatic activity. Defects in the gene encoding JNK3 are a cause of epileptic encephalopathy of the Lennox-Gastaut type, a group of epileptic disorders characterized by severe psychomotor delay and seizures.