Cytokeratin 15 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [ST04-85] (HA750182)

UNIPROT #

P19012

PROTEIN NAME

Cytokeratin 15

SYNONYMS

AI528832 antibody;CK 15 antibody;CK-15 antibody;CK15 antibody;Cytokeratin-15 antibody;Cytokeratin15 antibody;K15 antibody;K1C15_HUMAN antibody;K1CO antibody;Ka15 antibody;Keratin 15 antibody;Keratin 15 basic antibody;Keratin 15 beta antibody;Keratin antibody;Keratin complex 1 acidic gene 15 antibody;Keratin type I cytoskeletal 15 antibody;Keratin-15 antibody;Keratin15 antibody;KRT 15 antibody;Krt1-15 antibody;KRT15 antibody;KRTB antibody;KRTL15 antibody;Type I cytoskeletal 15 antibody;Type I keratin Ka15 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.

SUBCELLULAR LOCATION

Intermediate filament, cytosol, extracellular exosome, nucleus.

FUNCTION

Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.