FOXA1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JF10-02] (HA750363)

UNIPROT #

P55317

PROTEIN NAME

FOXA1

SYNONYMS

forkhead box A1 antibody;Forkhead box protein A1 antibody;FOX A1 antibody;FOXA1 antibody;FOXA1_HUMAN antibody;hepatocyte nuclear factor 3 alpha antibody;Hepatocyte nuclear factor 3-alpha antibody;HNF 3A antibody;HNF-3-alpha antibody;HNF-3A antibody;HNF3A antibody;MGC33105 antibody;TCF 3A antibody;TCF-3A antibody;TCF3A antibody;Transcription factor 3A antibody

TISSUE SPECIFICITY

Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. Mutations in this gene have been recurrently seen in instances of prostate cancer. Expression of FOXA1 correlates with two EMT markers, namely Twist1 and E-cadherin in breast cancer.