Phospho-ATM (S1981) Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JM93-25] (HA750432)

UNIPROT #

Q13315

PROTEIN NAME

Phospho-ATM (S1981)

SYNONYMS

A-T mutated antibody;A-T mutated homolog antibody;AT mutated antibody;AT1 antibody;ATA antibody;Ataxia telangiectasia mutated antibody;Ataxia telangiectasia mutated gene antibody;Ataxia telangiectasia mutated homolog (human) antibody;Ataxia telangiectasia mutated homolog antibody;ATC antibody;ATD antibody;ATDC antibody;ATE antibody;ATM antibody;ATM serine/threonine kinase antibody;ATM_HUMAN antibody;DKFZp781A0353 antibody;MGC74674 antibody;OTTHUMP00000232981 antibody;Serine protein kinase ATM antibody;Serine-protein kinase ATM antibody;Serine/threonine-protein kinase ATM antibody;Tefu antibody;TEL1 antibody;TEL1, telomere maintenance 1, homolog antibody;TELO1 antibody;Telomere fusion protein antibody

SEQUENCE SIMILARITIES

Belongs to the PI3/PI4-kinase family. ATM subfamily.

TISSUE SPECIFICITY

Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase. During the late stages of DNA damage response, dephosphorylated following deacetylation by SIRT7, leading to ATM deactivation.; Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP60. Deacetylated by SIRT7 during the late stages of DNA damage response, promoting ATM dephosphorylation and subsequent deactivation.

SUBCELLULAR LOCATION

Nucleus. Cytoplasmic vesicle.

FUNCTION

ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, NBS1 and H2AX are tumor suppressors. The ATM-mediated DNA damage response consists of a rapid and a delayed response. The protein kinase ATM may also be involved in mitochondrial homeostasis, as a regulator of mitochondrial autophagy (mitophagy) whereby old, dysfunctional mitochondria are removed. Increased ATM activity also occurs in viral infection where ATM is activated early during dengue virus infection as part of autophagy induction and ER stress response.