MBD1 Recombinant Rabbit Monoclonal Antibody [PSH01-78] - BSA and Azide free

Function

MBD1 is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Background References

1. Wensheng L, Bo Z, Qiangsheng H, et al. MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine. Cancer Cell Int. 2019 Sep 9; 19:232.

2. Lyst MJ, Nan X, Stancheva I. Retraction: Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins. EMBO J. 2019 Oct 15;38(20): e103220.

Subcellular Location

Nucleus, Nucleus matrix, Nucleus speckle, Chromosome

UNIPROT

SwissProt: Q9UIS9 Human

SwissProt: Q9Z2E2 Mouse

SwissProt: Q66HB8 Rat

Synonyms