FBXO3 Recombinant Rabbit Monoclonal Antibody [PSH04-09] - BSA and Azide free

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end.

Background References

1. Xu J et al. FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. PLoS Biol. 2023 Dec

2. Gao Y et al. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. Int J Mol Sci. 2022 Nov

Subcellular Location

Nucleus.

UNIPROT

SwissProt: Q9UK99 Human

SwissProt: Q9DC63 Mouse

Synonyms

F Box G - Domain 3 antibody

F box only protein 3 antibody

F box protein 3 antibody

F box protein FBX3 antibody

F-box only protein 3 antibody

FBA antibody

FBX3 antibody

FBX3_HUMAN antibody

FBXO3 antibody