SREBP1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH04-61] (HA750968)

UNIPROT #

P36956

PROTEIN NAME

SREBP1

SYNONYMS

ADD 1 antibody;bHLHd1 antibody;Class D basic helix-loop-helix protein 1 antibody;D630008H06 antibody;Processed sterol regulatory element-binding protein 1 antibody;SRBP1_HUMAN antibody;SREBF 1 antibody;SREBF1 antibody;SREBP 1 antibody;SREBP 1c antibody;SREBP-1 antibody;SREBP1 antibody;Sterol regulatory element binding protein 1 antibody;Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1 antibody;Sterol regulatory element binding transcription factor 1 antibody;Sterol regulatory element-binding transcription factor 1 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle, COPII-coated vesicle membrane; Nucleus.

FUNCTION

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. This gene is located within the Smith–Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. The isoforms are SREBP-1a and SREBP-1c (the latter also called ADD-1). SREBP-1a is expressed in the intestine and spleen, whereas SREBP-1c is mainly expressed in liver, muscle, and fat (among other tissues). SREBP-1 plays a key role in the induction of lipogenesis by the liver. mTORC1 is activated by insulin (a hormone of nutrient abundance) leading to increased production of SREBP-1c, which facilitates storage of fatty acids (excess nutrients) as triglycerides.