CD2 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH05-85] (HA751033)

UNIPROT #

P06729

PROTEIN NAME

CD2

SYNONYMS

CD 2 antibody;CD2 antibody;CD2 antigen (p50), sheep red blood cell receptor antibody;CD2 antigen antibody;CD2 molecule antibody;CD2_HUMAN antibody;Erythrocyte receptor antibody;FLJ46032 antibody;LFA-2 antibody;LFA-3 receptor antibody;LFA2 antibody;LFA3 receptor antibody;Ly-37 antibody;Lymphocyte function antigen 2 antibody;lymphocyte-function antigen-2 antibody;OTTHUMP00000024366 antibody;Rosette receptor antibody;Sheep erythrocyte receptor antibody;SRBC antibody;T cell surface antigen CD2 antibody;T-cell surface antigen CD2 antibody;T-cell surface antigen T11/Leu-5 antibody;T-lymphocyte surface CD2 antigen antibody;T11 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD2 is a transmembrane glycoprotein expressed early in thymocyte development and present on most circulating T cells. CD2 plays a role in T cell adhesion through binding to its ligand CD58 (LFA-3). Stimulation of CD2 also leads to T cell activation and proliferation. T cells from mice deficient in both CD2 and CD28 have severe defects in T cell activation and function, while T cells deficient in either CD2 or CD28 are still capable of mounting a response, suggesting that CD2 and CD28 may have overlapping functions and may be able to compensate for each other. In addition, engagement of CD2 and CD58 was recently demonstrated to be the primary costimulatory signal in T cells that lack CD28. CD2 expression also distinguishes a subset of plasmacytoid dendritic cells found in tumors and tonsils that express lysozyme, higher levels of IL-12 p40, and higher levels of CD80.