p75 NGF Receptor Recombinant Antibody [PSH13-26] - Rabbit IgG (Chimeric) - BSA and Azide free

Function

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms. Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.

Background References

1. Bruno F et al. The Nerve Growth Factor Receptor (NGFR/p75(NTR)): A Major Player in Alzheimer\'s Disease. Int J Mol Sci. 2023 Feb

2. Castellini C et al. The Effect of Interaction NGF/p75(NTR) in Sperm Cells: A Rabbit Model. Cells. 2022 Mar

Subcellular Location

Cell membrane, Cytoplasm, Perikaryon, Cell projection, growth cone, dendritic spine.

UNIPROT

SwissProt: Q9Z0W1 Mouse

Synonyms