TRAIL Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH14-40] (HA751522)

UNIPROT #

P50591

PROTEIN NAME

TRAIL

SYNONYMS

Apo 2 ligand antibody;APO 2L antibody;Apo-2 ligand antibody;Apo-2L antibody;APO2L antibody;CD253 antibody;CD253 antigen antibody;Chemokine tumor necrosis factor ligand superfamily member 10 antibody;Protein TRAIL antibody;TL2 antibody;TNF Related Apoptosis Inducing Ligand antibody;TNF related apoptosis inducing ligand TRAIL antibody;TNF-related apoptosis-inducing ligand antibody;TNF10_HUMAN antibody;TNFSF10 antibody;TRAIL antibody;Tumor necrosis factor (ligand) family member 10 antibody;Tumor Necrosis Factor (ligand) Superfamily Member 10 antibody;Tumor necrosis factor apoptosis inducing ligand splice variant delta antibody;Tumor necrosis factor ligand superfamily member 10 antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis. TRAIL is a cytokine that is produced and secreted by most normal tissue cells. It causes apoptosis primarily in tumor cells, by binding to certain death receptors. TRAIL and its receptors have been used as the targets of several anti-cancer therapeutics since the mid-1990s, such as Mapatumumab. However, as of 2013, these have not shown significant survival benefit. TRAIL has also been implicated as a pathogenic or protective factor in various pulmonary diseases, particularly pulmonary arterial hypertension. TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, member 10).