HBEGF Rabbit Polyclonal Antibody
Catalog# ER61976
HBEGF Rabbit Polyclonal Antibody
-
WB
-
Human
-
Rat
-
Mouse
-
unconjugated
Overview
Product Name
HBEGF Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthesized peptide derived from human protein . at AA range: 130-210
Species Reactivity
Human, Rat, Mouse
Validated Applications
WB
Molecular Weight
22 kDa
Positive Control
Brain,Eye,Histiocytic lymphoma,Macrophage,
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
-
WB
-
1:500-1:2000
Target
Function
May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937). PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active. Contains 1 EGF-like domain. subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Background References
暂无
UNIPROT
Synonyms
diphtheria toxin receptor (heparin-binding EGF-like growth factor) antibody
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) antibody
Diphtheria toxin receptor antibody
DT R antibody
DT-R antibody
DTR antibody
DTS antibody
DTSF antibody
HB-EGF antibody
HBEGF antibody
ExpandImages
-
Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
HBEGF Recombinant Rabbit Monoclonal Antibody [JE34-79]
Application: WB,IHC-P
Reactivity: Human,Rat
Conjugate: unconjugated
Products with the same target and pathway