HIF-1 alpha Mouse Monoclonal Antibody [5H7]

Function

Cell growth and viability is compromised by oxygen deprivation (hypoxia).Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1),EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes,thereby activating transcription. Hypoxia-inducible expression of some genes,such as Glut-1, p53, p21 or Bcl-2, is HIF-1α dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1α independent. EPAS-1 and HIF-3α have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.

Background References

1. Yang, Q.C., et al. 2007. Overexpression of hypoxia-inducible factor-1α in human osteosarcoma: correlation with clinicopathological parameters and survival outcome. Jpn. J. Clin. Oncol. 37: 127-134.

2. De Spiegelaere, W., et al. 2010. Localization of erythropoietin in and around growing cartilage. Mol. Cell. Biochem. 337: 287-291.

3. Foti, R., et al. 2010. Parkinson’s disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. J. Biol. Chem. 285: 18565-18574.

Subcellular Location

Cytoplasm, Nucleus, Nucleus speckle

UNIPROT

SwissProt: Q16665 Human

Synonyms