HSF1 Mouse Monoclonal Antibody [4D-5F]

Function

Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors 1 and 2 (HSF1 and HSF2), also designated HSTF1 and HSTF2, are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer, whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway

Background References

1. Takii R et al. ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol 35:11-25 (2015).

2. Aguilà M et al. Hsp90 inhibition protects against inherited retinal degeneration. Hum Mol Genet 23:2164-75 (2014).

Subcellular Location

Nucleus, cytoplasm.

UNIPROT

SwissProt: Q00613 Human

Synonyms

Heat shock factor 1 antibody

Heat shock factor protein 1 antibody

Heat shock transcription factor 1 antibody

HSF 1 antibody

hsf1 antibody

HSF1_HUMAN antibody

HSTF 1 antibody

HSTF1 antibody