Histone H2A Acetyl Rabbit Polyclonal Antibody

Function

Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA sequentially in a left-handed super-helical turn to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3 and H4) form the octamer, which is comprised of two H2A-H2B dimers and two H3-H4 dimers, creating two nearly symmetrical halves by tertiary structure. More than 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.

Background References

1. Huo, L.R., et al. 2010. Identification of differentially expressed transcripts and translatants targeted by knock-down of endogenous PCBP1. Biochim. Biophys. Acta 1804: 1954-1964.

2. Huo, L.R., et al. 2008. Identification of transcripts and translatants targeted by overexpressed PCBP1. Biochim. Biophys. Acta 1784: 1524-1533.

Subcellular Location

Nucleus. Chromosome.

UNIPROT

SwissProt: P27661 Mouse

Synonyms

H2A histone family member X antibody

H2A histone family member X antibody

H2A.FX antibody

H2A.X antibody

H2a/x antibody

H2AFX antibody

H2AX antibody

H2AX_HUMAN antibody

Histone H2A.X antibody