Biotin Conjugated Human GITR Recombinant Rabbit Monoclonal Antibody [PSH05-64]

Function

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Background References

1. Ming S., Yin H., Li X., Gong S., Zhang G., Wu Y. GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis. Front Immunol 12:736269-736269 (2021).

2. Bosmans L.A., Shami A., Atzler D., Weber C., Goncalves I., Lutgens E. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. Vascul Pharmacol 139:106884-106884 (2021).

Subcellular Location

Cell membrane, Secreted.

UNIPROT

SwissProt: Q9Y5U5 Human

Synonyms