Biotin Conjugated Human MMP-8 Recombinant Rabbit Monoclonal Antibody [PSH03-34]

Function

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Background References

1. Zhao Y., Zhang Q., Zhang X., Zhang Y., Lu Y., Ma X., Li W., Niu X., Zhang G., Tian Y. The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility. Brain Behav 12:e2797-e2797 (2022)

2. Maghajothi S., Subramanian L., Mani P., Singh M., Iyer D.R., Sharma S., Khullar M., Victor S.M., Asthana S., Mahapatra N.R. A common Matrix metalloproteinase 8 promoter haplotype enhances the risk for hypertension via diminished interactions with nuclear factor kappa B. J Hypertens 40:2147-2160 (2022)

Subcellular Location

Secreted

UNIPROT

SwissProt: P22894 Human

Synonyms