IL-31 Mouse Monoclonal Antibody [B7-B0]
Catalog# M1305-3
IL-31 Mouse Monoclonal Antibody [B7-B0]
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WB
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ELISA
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Human
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unconjugated
Overview
Product Name
IL-31 Mouse Monoclonal Antibody [B7-B0]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein within Human Interleukin 31 aa 1-164 / 164.
Species Reactivity
Human
Validated Applications
WB, ELISA
Molecular Weight
Predicted band size: 18 kDa
Positive Control
Bioactive recombinant human IL-31 protein.
Conjugation
unconjugated
Clone Number
B7-B0
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG2a
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:2,000
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ELISA
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1:5,000-1:10,000
Target
Function
Interleukin 31 (IL-31) is a secreted, T-cell-derived, short-chain member of the alpha-helical family of cytokines. The mature region is 141 amino acids (aa) in length and exhibits four alpha-helices. Human and mouse IL-31 are highly divergent at 24% aa sequence identity. The receptor for IL-31 is found on keratinocytes and monocytes. It is a heterodimer composed of the Oncostatin M receptor and a novel gp130-related molecule. IL-31 may be involved in pruritis, or skin itching.
Background References
1. "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis." Bilsborough J., Leung D.Y.M., Maurer M., Howell M., Boguniewicz M., Yao L., Storey H., LeCiel C., Harder B., Gross J.A. J. Allergy Clin. Immunol. 117:418-425(2006)
2. "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice." Dillon S.R., Sprecher C., Hammond A., Bilsborough J., Rosenfeld-Franklin M., Presnell S.R., Haugen H.S., Maurer M., Harder B., Johnston J., Bort S., Mudri S., Kuijper J.L., Bukowski T., Shea P., Dong D.L., Dasovich M., Grant F.J. Gross J.A. Nat. Immunol. 5:752-760(2004)
Tissue Specificity
Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
Subcellular Location
Secreted.
UNIPROT
Synonyms
IL 31 antibody
IL-31 antibody
IL31 antibody
IL31_HUMAN antibody
Interleukin 31 antibody
Interleukin-31 antibody
Images
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Western blot analysis on bioactive recombinant human IL-31 protein using anti-IL-31 Mouse mAb (Cat. # M1305-3).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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