IL17 Mouse Monoclonal Antibody [4G2]

Function

Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.

Background References

1. Yao, Z., et al. 1996. Complete nucleotide sequence of the mouse CTLA8 gene. Gene. 168: 223-225.

2. Ihle, J.N. 1996. Janus kinases in cytokine signalling. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 351: 159-166.

3. Cohen, M.C., et al. 1996. Cytokine function: a study in biologic diversity. Amer. J. Clin. Pathol. 105: 589-598.

Subcellular Location

Secreted

UNIPROT

SwissProt: Q16552 Human

Synonyms