Chromogranin A Mouse Monoclonal Antibody

Function

Strongly inhibits glucose induced insulin release from the pancreas.Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa . Can induce mast cell migration, degranulation and production of cytokines and chemokines . Acts as a potent scavenger of free radicals in vitro tion and blood pressure .Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.

Background References

1. Briolat J. et. al. New antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A. Cell. Mol. Life Sci. 62:377-385(2005).

Subcellular Location

Cytoplasmic vesicle, Secreted.

UNIPROT

SwissProt: P26339 Mouse

Synonyms