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ZEB Recombinant Rabbit Monoclonal Antibody

Usd: 208

Specification

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Catalog# IRS245RB

ZEB Recombinant Rabbit Monoclonal Antibody

Application

  • mIHC

Reactivity

  • Mouse

Conjugation

  • unconjugated

Overview

Product Name

ZEB Recombinant Rabbit Monoclonal Antibody

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Recombinant protein within human ZEB1 aa 1-400 / 1,124.

Species Reactivity

Mouse

Validated Applications

mIHC

Molecular Weight

Predicted band size: 124 kDa

Positive Control

Jurkat cell lysate, SK-OV-3 cell lysate, HeLa cell lysate, HEK-293 cell lysate, U87-MG cell lysate, MG-63 cell lysate, human colon tissue, human kidney tissue, human ovary carcinoma tissue, mouse heart tissue, mouse kidney tissue, mouse liver tissue, mouse lung tissue, mouse stomach tissue, mouse testis tissue, rat kidney tissue, rat liver tissue, rat lung tissue, rat small intestine tissue, rat testis tissue, Jurkat.

Conjugation

unconjugated

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • mIHC

  • 1:100

Target

Function

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain. The structure of the homeodomain is shown on the right. Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas A recent study suggested its contributing role in lung cancer invasiveness and metastasis development. Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.

Background References

1. Zhang Y et al. Expression and Function of ZEB1 in the Cornea. Cells. 2021 Apr

2. Cheng P et al. ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis. Circulation. 2022 Feb

Subcellular Location

Nucleus.

UNIPROT

SwissProt: Q64318 Mouse

SwissProt: Q9R0G7 Mouse

Synonyms

AREB 6 antibody

AREB6 antibody

BZP antibody

Delta crystallin enhancer binding factor 1 antibody

DELTA EF1 antibody

FECD6 antibody

MGC133261 antibody

Negative regulator of IL 2 antibody

Negative regulator of IL2 antibody

NIL 2 A antibody

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"