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IL-6 Mouse Monoclonal Antibody [3-A4]

Usd: 350

Specification

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Catalog# M1303-3

IL-6 Mouse Monoclonal Antibody [3-A4]

Application

  • WB

  • IF-Cell

  • FC

  • ELISA

Reactivity

  • Mouse

Conjugation

  • unconjugated

This product has been cited in peer reviewed publications, see list HERE

Overview

Product Name

IL-6 Mouse Monoclonal Antibody [3-A4]

Antibody Type

Mouse Monoclonal Antibody

Immunogen

Recombinant protein within Mouse IL-6 aa 1-211 / 211.

Species Reactivity

Mouse

Validated Applications

WB, IF-Cell, FC, ELISA

Molecular Weight

Predicted band size: 24 kDa

Positive Control

Bioactive mouse IL-6 protein.

Conjugation

unconjugated

Clone Number

3-A4

RRID

AB_3073056

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG2b

Purification Method

Protein A affinity purified.

Application Dilution

  • WB

  • 1:10,000

  • ELISA

  • 1:1,000-1:10,000

  • FC

  • 1:1,000

  • IF-Cell

  • 1:50-1:200

Target

Function

Interleukin 6 (IL-6) is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6 is a cytokine with a wide variety of biological functions and belongs to the?IL-6 superfamily. IL-6 is a potent inducer of the acute phase response and plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. This antibody can recognize mouse interleukin 6, which is a matched antibody-pair with product cat # M1303-1.

Background References

1. "The murine Il-6 gene maps to the proximal region of chromosome 5."Mock B.A., Nordan R.P., Justice M.J., Kozak C., Jenkins N.A., Copeland N.G., Clark S.C., Wong G.G., Rudikoff S.J. Immunol. 142:1372-1376(1989)

2. "Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human."Tanabe O., Akira S., Kamiya T., Wong G.G., Hirano T., Kishimoto T.J. Immunol. 141:3875-3881(1988)

Sequence Similarity

Belongs to the IL-6 superfamily.

Subcellular Location

Secreted.

UNIPROT

SwissProt: P08505 Mouse

Synonyms

Interleukin BSF 2 antibody

B cell differentiation factor antibody

B cell stimulatory factor 2 antibody

B-cell stimulatory factor 2 antibody

BSF 2 antibody

BSF-2 antibody

BSF2 antibody

CDF antibody

CTL differentiation factor antibody

Hepatocyte stimulatory factor antibody

Expand

Images

  • Western blot analysis on bioactive mouse IL-6 protein using anti-IL-6 Mouse mAb (Cat. # <a href="/products/M1303-3" style="font-weight: bold;text-decoration: underline;">M1303-3</a>).

    Western blot analysis on bioactive mouse IL-6 protein using anti-IL-6 Mouse mAb (Cat. # M1303-3).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Citation