KLHL12 Mouse Monoclonal Antibody [B1-G2]

Function

KLHL12 (kelch-like protein 12), also known as C3IP1 (CUL3-interacting protein 1), DKIR or FLJ27152, is a 568 amino acid protein that is a component of an ubiquitin-protein E3 ligase complex, which includes at least CUL-3. KLHL12 is a substrate-specific adapter for the complex, which negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of Dvl-3. KLHL12 contains six Kelch repeats and one BTB (POZ) domain, which is required for interaction with CUL-3. KLHL12 has highest expression in testis, with lower levels found in the submandibular salivary gland. The gene that encodes KLHL12 maps to human chromosome 1q32.1.

Background References

1. Mai A et al. hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure. Exp Cell Res 300(1):72-83 (2007).

2. Maruyama K et al. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 138(1-2):171-4 (2007).

Subcellular Location

Cytoplasmic vesicle.

UNIPROT

SwissProt: Q53G59 Human

Synonyms