Ki67 Rabbit Polyclonal Antibody

Function

Ki-67 is a nuclear protein that is expressed in proliferating cells and may be required for maintaining cell proliferation. Ki-67 has been used as a marker for cell proliferation of solid tumors and some hematological malignancies. A correlation has been demonstrated between Ki-67 index and the histopathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors.

Background References

1. Ren, G., et al. 2012. A micro-RNA connection in BRaf(V600E)-mediated premature senescence of human melanocytes. Int. J. Cell Biol. 2012: 913242.

2. Lee, J.S., et al. 2012. Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation. Stem Cell Rev. 8: 532-545.

Subcellular Location

Nucleus, Chromosome

UNIPROT

SwissProt: P46013 Human

Synonyms