LY6A Recombinant Rabbit Monoclonal Antibody [JM53-11]

Function

The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily. The Ly-6 alloantigens represent a family of phosphatidylinositol anchored proteins that play a role in the process of T lymphocyte activation. Ly-6 expression is commonly induced on T and B lymphocytes after activation by mitogens. Ly-6A/E is a phosphatidylinositol-linked transmembrane member of the Ly-6 family that is produced in humans after 4 weeks of age. γ-interferon and TNF regulate Ly-6A/E at the level of transcription and mRNA stabilization in certain thymocytes and T-cells.

Background References

1. Neirinckx V et al. Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury. Stem Cell Res Ther 6:211 (2015).

2. Malliaras K et al. Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. EMBO Mol Med 6:760-77 (2014).

Tissue Specificity

Widely expressed.

Post-translational Modification

O-glycosylated. Not N-glycosylated.; Not phosphorylated.

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P05533 Mouse

Synonyms